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Creamy Salmon Casserole for Your Brain (and Soul) | Mental Health Recipes

By Krista

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Last Updated: May 13, 2025

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Sometimes, the best medicine can be found in our food itself.

Casseroles come together with minimal effort (and make plenty of portions for leftovers!). Whether you’re a fan of salmon, or not, you’re going to love this one.

In fact, if you hate salmon, this recipe disguises it for the most part, helping you get all those brain-supporting nutrients that this fish has to offer without the potentially overpowering flavor.

Personally, I love salmon. But sometimes, a casserole is exactly the comforting type of food I need.

This one’s got all of the goodness of comfort foot but with an added benefit: it’s also packed with omega-3s, thanks to salmon. So, how can you make this yummy and easy dish? How can it support your mental health? Let’s dive in!

 

The Best Creamy Salmon Casserole

It doesn’t take too much to make this casserole. And you’re rewarded with nine whole servings - that's lunch and dinners for potentially multiple days. If you’ve got a bigger family, you can even double up the recipe.

 

Can This Creamy Salmon Casserole Contribute to a Better Mood?

In short, yes! This creamy salmon casserole is packed with nutrients that can genuinely enhance your mental well-being and potentially uplift your mood. So, how does each ingredient do this?

Here are the details, broken down by each nutrient.

 

Omega-3 Fatty Acids Provide Healthy Fats

Salmon is one of the richest sources of omega-3 fatty acids available, particularly EPA and DHA. These essential fatty acids are critical components of brain cell membranes and promote better communication between brain cells.

Research consistently shows that omega-3s can help reduce symptoms of depression and anxiety. In fact, countries with high fish consumption tend to have lower rates of depression (also known as the “blue zones”).

The truth of the matter is that omega-3s help reduce inflammation in the brain, which is increasingly linked to mood disorders.

So… you can think about it this way: When you’re feeling low, your brain might actually be craving these essential fatty acids. The rich, flaky salmon in this casserole delivers just what your neurons need to function optimally. Aim for wild-caught salmon when possible, as it typically contains higher levels of these beneficial fats (and less mercury!).

Related Article: Nourish Your Neurons: Miso-Glazed Salmon for Better Mental Health | Mental Health Recipe

 

Protein for Repair & Regeneration

This salmon casserole offers substantial protein, which does wonders for mood regulation in multiple ways.

For example, protein breaks down into amino acids, which are the building blocks for neurotransmitters like serotonin and dopamine - your brain's natural mood enhancers. 

Additionally, protein helps stabilize blood sugar. Those energy crashes that leave you irritable and foggy-brained? Protein helps prevent them by slowing digestion and providing a steady release of energy. 

 

B Vitamins for More Energy

Salmon is rich in several B vitamins, particularly B12, which plays an important role in brain function and the production of DNA and red blood cells. In fact, B12 deficiency has been linked to depression, irritability, and even memory problems.

The creamy base of this casserole also contains B vitamins, thanks to the milk and cheese. These vitamins help convert food into energy for your brain cells, supporting cognitive function and helping ward off fatigue.

 

Vitamin D for a Bit of Sunshine

Living in areas with limited sunlight? Salmon has you covered there, too! It’s one of the few food sources that naturally contains vitamin D, often called the “sunshine vitamin.”

Low vitamin D levels have been consistently linked to depression and seasonal affective disorder. During winter months or if you’re spending most of your time indoors, incorporating vitamin D-rich foods like salmon becomes even more important for emotional stability.

 

Complex Carbohydrates for a Better Mood

The vegetables and any whole grains you include in this casserole provide complex carbohydrates, which stimulate the production of serotonin - a neurotransmitter that promotes feelings of happiness and well-being.

Unlike simple carbs that cause blood sugar spikes and crashes (hello, mood swings!), the complex carbs in this dish release glucose slowly, providing steady energy and helping maintain stable moods throughout the day.

The fiber in these complex carbs also supports gut health; a healthy gut microbiome communicates directly with your brain, influencing mood, stress response, and even cognitive function!

 

Calcium for Your Nervous System

The creamy element of this casserole typically contains calcium-rich ingredients like milk or cheese.

Calcium isn’t just for strong bones - it also plays a role in nerve function and neurotransmitter release. When calcium levels are optimal, your nervous system functions more efficiently, potentially reducing anxiety and improving overall mood regulation.

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Creamy Salmon Casserole

Prep time:
10-15 minutes
Cook time:
Total time:
45-60 minutes
Recipe Category:
salmon
Ingredients:
  • 2 cups of uncooked macaroni
  • 14 ½ ounces of canned salmon
  • 2 cups of shredded Monterey Jack cheese

For the Sauce:

  • 2 tablespoons of butter
  • ¼ cup of onion (minced)
  • 1 tablespoon of flour
  • 1 cup of low-fat milk
  • 1 tablespoon of lemon juice
  • 1 tablespoon of fresh parsley (finely chopped)

 

Instructions:
  1. Cook the macaroni per the directions on the box or bag.
  2. Drain the canned salmon and ensure it’s in small pieces.
  3. Now, it’s time to make the sauce! Start by melting the butter in a saucepan, then cooking the onion until it's translucent. Add the flour, then slowly stir in the milk. Keep cooking until it’s nice and thick, then add the lemon juice and parsley. Mix well and set aside.
  4. Add the pasta to a casserole dish.
  5. Place the salmon on top.
  6. Add a layer of half of the Monterey Jack cheese.
  7. Pour the sauce on top.
  8. Add the remaining cheese to the top.
  9. Bake at 350 ℉ for 25 minutes or until the cheese is brown on top. Then, enjoy!

Related Article: Yummy One-Pan Creamy Salmon Spinach: Get Yourself Out of That Funk!

Yield (servings):
9 servings

Make This Comforting Dish Today!

Whether you like salmon or not, I recommend trying this one. It’s a great way to get your omega-3s, which, in turn, boosts brain health and mental health—helping you feel calm, happy, and collected. 

Read Next: Calm Your Worries With This Easy Honey Garlic Salmon | Mental Health Recipes

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